Bioestatistics and Biomathematics Research Group

Selected publications

• Salvado B, Vilaprinyo E, Karathia H, Sorribas A, Alves R (2012) Two Component Systems: Physiological Effect of a Third Component. PLoS ONE 7(2): e31095. doi:10.1371/journal.pone.0031095
• Pozo C, Marin-Sanguino A, Guillén-Gosalbez G, Jimenez L, Alves R, Sorribas A. Steady-state global optimization of non-linear dynamic models through recasting into power-law canonical models. (2011) BMC Systems Biology 5:137
• Salvado B, Karathia H, Usie-Chimenos A, Vilaprinyo E, Omholt S, Sorribas A, Alves R. Methods for and results from the study of design principles in molecular systems. (2011) Mathematical Biosciences 231:3–18
• Karathia HM, Vilaprinyo E, Sorribas A, Alves R. S. cerevisiae as a model organism: Strengths & drawbacks (2011) PLoS One 6(2):e16015
• Vilaprinyo E, Alves R, Sorribas A. Minimization of biosynthetic costs in adaptive gene expression responses of yeast to environmental changes. (2010)
  PLoS Computational Biology 6(2): e1000674. doi:10.1371/journal.pcbi.1000674
• Sorribas A, Pozo C, Vilaprinyo E, Guillén-Gosálbez G, Jimenez L, Alves R. Optimization and evolution in metabolic pathways: global optimization techniques in Generalized Mass Action models. Journal of Biotechnology 149(3):141-153
• Guillén-Gosálbez-G, Sorribas, A. Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses. BMC Bioinformatics 2009, 10:386
• Alves R, Vilaprinyo E, Sorribas A, Herrero E. Evolution based on domain combinations: the case of glutaredoxins.BMC Evolutionary Biology 2009, 9:66
• Alves R, Sorribas A In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae. BMC Systems Biology 2007 Jan 31;1:10.
• Sorribas A, Hernandez-Bermejo B, Vilaprinyo E, Alves R. Cooperativity and saturation in biochemical networks: A saturable formalism using Taylor series approximations. Biotechnol Bioeng. 2007 Aug 1;97(5):1259-77.
• Vilaprinyo E, Alves R, Sorribas A. Use of physiological constraints to identify quantitative design principles for gene expression in yeast adaptation to heat shock.
  BMC Bioinformatics. 2006 Apr 3;7:184.
• Alves R, Herrero E, Sorribas A. Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism. II. Role of glutaredoxin Grx5. Proteins. 2004 Nov 15;57(3):481-92.
• Alves R, Herrero E, Sorribas A. Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism: I. The role of the protein pair ferredoxin-ferredoxin reductase (Yah1-Arh1). Proteins. 2004 Aug 1;56(2):354-66.